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KMID : 0981420000020010065
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Schizophrenia Clinics
2000 Volume.2 No. 1 p.65 ~ p.75
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Changes of Positive and Negative Symptoms in the Long-Term Treatment Course of Schizophrenia
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Jung Young-In
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Abstract
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The positive-negative syndrome distinction is an important organizing construct in understanding the heterogeneity of schizophrenia. The positive and negative syndromes appear to have distinct clinical and path ophysiological correlates, and different prognostic implications and course. Substantial data support the distinction between these two syndromes. In a given schizophrenic patient, however, the two syndromes are not mutually exclusive and often coexist, and relative proportions and actual magnitude of two syn-2 dromes vary throughout the course of the illness. A longitudinal perspective and frame on- Work of overall clinical state are, therefore, important in the assessment and effective of management of schizophrenic symptoms. First admission studies in schizophrenia have PP the advantage of allowing the investigation of approximately identical phases of illness, as it is the first episode that usually leads to the first admission. Also, the earliest symp tomatology of schizophrenia may provide more direct clues to the symptom process and to underlying pathophysiology than are provided by symptomatology later in the course of illness, as the early course is less influenced by environmental factor, biological factor, in and coping behavior than is the later course. Negative symptoms are prominent in untreated acute first-episode and recent onset patients with schizophrenia. In the earlyive course of treatment, negative symptoms show a modest improvement, but tend to be more treatment resistant compared with positive symptoms. Also, negative symptoms tend to be more stable and persistent throughout the overall course of treatment. From in a longitudinal perspective, negative symptoms appear to be heterogeneous with different at pathophysiological mechanisms. Persistent negative symptoms in the later course of treatment might be deficit syndromes that reflect deterioration and decline from premorbid levels of functioning. Although there appears to be no effective PharmacotheraPv for deficit syndromes, it may be possible to prevent or delay the development of such syndromes by rapid effective treatment in the psychotic phase of the illness.
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KEYWORD
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Positive symptom, Negative symptom, Treatment course, Schizophrenia
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FullTexts / Linksout information
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Listed journal information
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